KLK3 and cancer: A study that verified the geographic pattern and trends for prostate cancer in South and Central America confirmed that the 3–5% increase in the annual incidence of this cancer, along with the maintenance of constant mortality rates between 1997 and 2008, in countries such as Brazil, Argentina, Chile and Costa Rica, was partly due to screening with DRA and/or PSA, and this incidence should continue to increase due to these practices [2].