BRAF and neoplasm: While post-surgical staging is the mainstay of prognostication in most clinical centres, the potential for refining prognostication using molecular features has been widely investigated, and the combined use of different clinical and molecular markers have shown links with prognosis in CRC, e.g. while BRAF mutations have been associated with poorer outcome [26], the effects of these mutations may be mitigated in MSI tumours [27].