CASR and metabolic syndrome: It has to be stressed, however, that the fifth-class associations by the BADGE system [30], like those between CASR rs7652589 and atherogenic dyslipidemia, CASR rs1801725 and dyslipidemia diagnosed by non-HDL-cholesterol ≥130 mg/dL and TG ≥ 200 mg/dL, and CASR rs1801725 and CAD prevalence, do not provide assurance of reproducibility.