In omental adipose tissue obtained from individuals without end-stage renal disease, the CASR rs1042636 major homozygosity (AA) was associated with a lower frequency of CaSR responsiveness to the antilipolytic effect of cinacalcet, whereas the rs1042636 variant allele (G) was associated with a greater antilipolytic frequency. Here, CASR is linked to stage 5 chronic kidney disease.