Subjects showing homozygosity of the variant allele of CASR rs1801725 revealed 6.8-fold lower prevalence of CAD than those with homozygosity of the major allele as well as the 6.5-fold lower frequency of CAD than those being the major homozygotes and heterozygotes of CASR rs1801725 (Additional file 1: Table S7). Here, CASR is linked to coronary artery disorder.