The aim of our study was to investigate whether CASR SNPs (rs1801725, rs7652589) are associated with dyslipidemia in HD patients, or whether there is any interaction between CASR and other genes known as associated with lipogenesis, like ENHO, retinoid X receptor α gene (RXRA), or liver X receptor α gene (LXRA). The gene discussed is NR1H3; the disease is metabolic syndrome.