This meta-study is consistent with previous study of meta-analysis [40], which might support that the MTHFR C677T mutation is likely to be a direct genetic risk factor of ischemic stroke [33] and TT genotype would become a promising biomarker for the early detection and prediction of the prognosis of ischemic stroke as well as regarding to safely conducting future prospects of research [39] in the elderly population. The gene discussed is MTHFR; the disease is ischemic stroke.