The subgroup results in the Chinese population similarly showed that MTHFR C677T variant and T-allele expression were significantly associated with elevated risk of ischemic stroke as follows: CT + TT versus CC, OR 1.32, 95%CI 1.09–1.59, Fig. 2a; CT vs. CC, OR 1.26, 95%CI 1.03–1.54, Fig. 2b; TT versus CC, OR 1.48, 95%CI 1.14–1.92, Fig. 2c; TT versus CC + CT: OR 1.28, 95%CI 1.02–1.62, Fig. 2d; T-allele vs. C-allele: OR 1.22, 95%CI 1.08–1.39, Fig. 2e. Here, MTHFR is linked to ischemic stroke.