In recent work on glioblastoma cancer stem-like cells (GCSCs), able to promote their own proliferation by secreting vascular endothelial growth factor A (VEGF-A) in an autocrine manner, positively regulated also by PDE4, the authors demonstrate that rolipram and bevacizumab, a VEGF-A factor blocker, act in a synergistic manner, inducing glioblastoma cell death [105]. Here, PDE4A is linked to glioblastoma.