NF-κB-dependent pathway suppression after quercetin-loaded nanoparticles or quercetin combination therapy was also observed by two groups [42,47], however this route has not been analyzed in HCC cells treated with quercetin alone, despite the well-known role of signaling routes such as JAK/STAT and NF-κB pathways in liver cancer development [67]. This evidence concerns the gene SOAT1 and hepatocellular carcinoma.