Its wide distribution in various tissues and sites (bone marrow, small intestine, kidney, liver, blood vessels, body fluids, epithelial and endothelial cells) in the body, as well as reported effects on energy metabolism and insulin action has made DPP-IV become an interesting pharmacotherapeutic target in diabetes mellitus (DM) treatment and management [13,14,15]. The gene discussed is INS; the disease is diabetes mellitus.