TIMD4 and allergic disease: TIM‐1 was found to be expressed on activated Th2 cells, whereas TIM‐4 is not expressed on T cells but is primarily found on antigen‐presenting cells (APCs) (ie macrophages and dendritic cells).9 Previous studies have implicated TIMs in the regulation of certain immune responses, including allergy, asthma, autoimmunity and transplant tolerance.8, 10 Recent studies suggest that the TIM‐4 pathway plays an important role in IRI of the liver and kidney.