Conversely, the GACC haplotype, which represents the combination of the ITGAM rs34572943G, rs1143679A, rs9888739C, and rs1143679C alleles, showed an association with protection against RA even after correction with the Bonferroni test (OR = 0.14, p = 0.0003). This evidence concerns the gene ITGAM and rheumatoid arthritis.