Thus, this gene is well known to be one of the main SLE-susceptibility loci. ITGAM encodes CD11b, a component of the macrophage-1 antigen complex (Mac1, also known as complement receptor 3 [CR3]), which together with CD18, form Mac-1 or CR3, a protein that mediates leukocyte adhesion, migration, and phagocytosis in different cells including neutrophils, monocytes, macrophages, and dendritic cells [4,34–36]. This evidence concerns the gene CRIPTO3 and systemic lupus erythematosus.