FBN1 and scoliosis: Our study expands the mutational spectrum of FBN1 and highlights the potential molecular mechanism for MPLS subjects, which facilitates our understanding of genotype–phenotype correlations in FBN1 to provide effective genetic counseling, implementation and timing of therapy (e.g. mitigation of TGF‐β hypersignaling, surgical intervention for cardiovascular complications or for scoliosis), or early intervention.