Aged Hv1 knockout mice showed smaller neuronal damage in brain ischemia, while young Hv1 knockout animals did not show any difference compared with young wild‐type mice.33 A novel observation in our study is that the percentage of CD16/32‐positive M1 microglia colabeling with Hv1 was higher in aged mice compared with adult mice after tibial fracture surgery. Here, HVCN1 is linked to brain ischemia.