Further research revealed that SNHG15 downregulation can lead to decreased EZH2 binding and H3K27me3 occupancy of the P15 and KLF2.41 These findings indicated that lncRNA SNHG15 can repress P15 and KLF2 through EZH2‐mediated H3K27me3, thus contributing to PC cell proliferation. This evidence concerns the gene EZH2 and pachyonychia congenita.