Recently, Ye et al reported the specific function and molecular mechanism of SNHG15 in hepatocellular carcinoma.74 SNHG15 was shown to exhibit oncogenic properties in hepatocellular carcinoma (HCC) by sponging tumour‐suppressive miR‐141‐3p, in turn, increasing ZEB2 and E2F3 expression.74 Furthermore, the suppression of miR‐141‐3p can partially reverse the inhibitory influence of HCC carcinogenesis driven by SNHG15 knockdown.74 The interplay of SNHG15/miR‐141‐3p/mRNA ZEB2/E2F3 in HCC may add another layer of ceRNA regulation, facilitating the understanding of HCC pathogenesis. This evidence concerns the gene E2F3 and hepatocellular carcinoma.