As a dysregulated lncRNA in PC, knockdown of SNHG15 could impair PC cell proliferation, cause G1/G0 phase arrest and activate apoptosis.41 Besides, overexpression of SNHG15 was observed to boost the proliferative capacity of PC cells through regulating cell cycle and apoptosis correlated proteins, presenting as the reduction of P15 and KLF2.41 The SNHG15 impact can be partly reversed by overexpression of P15 or KLF2.41 Consistently, SNHG15 exhibited a negative correlation with P15 or KLF2 in PC tissues. The gene discussed is KLF2; the disease is pachyonychia congenita.