Upon in‐vivo assay, SNHG15 knockdown could exhibit suppressive effects on tumour growth in PC.41 Mechanistically, a SNHG15/EZH2/P15/KLF2 axis was identified in PC, shedding new light on lncRNA‐based diagnosis and therapeutic in PC.41 Here, KLF2 is linked to pachyonychia congenita.