Only the Fluzone/CLDC‐vaccinated animals had lower virus replication when challenged with H1N1 influenza viruses.76 In another study, vaccination with liposomes containing HA and NA from various influenza strains and IL‐2/GM‐CSF as an adjuvant (INFLUSOME‐VAC) resulted in increased HAI titers compared to the control groups that received commercial influenza vaccines.77 This evidence concerns the gene CSF2 and influenza.