TGFB1 and gastric cancer: Through integrative gene expression and mutational analysis of diffuse-type GC, we discovered a number of distinct molecular features of the INT subtype, such as high TMB, enrichment of MSI or EBV molecular subtypes, activation of DDR genes, and inactivation of the TGFB1 pathway along with its downstream effectors related to EMT activity, indicating favorable responsiveness to ICI treatment in the INT subtype.