MUC16 and gastric cancer: The total mutation rate of MUC16 in the diffuse-type GC patients was 31.1%, and the mutation frequency of MUC16 in the COD subtype was significantly higher than that in the INT subtype (Fisher exact test; P = 0.002), suggesting that the MUC16 variant is a good indicator discriminating diffuse-type GC of the INT subtype from that of the COD subtype.