Bioinformatic and luciferase reporter analyses showed that YWHAE (14-3-3e), a member of the 14-3-3 protein family, was the direct target of miR-6778-5p, which mediated the function of miR-6778-5p in proliferation of colon cancer cells through inhibiting the activation of p38 MAP kinase. The gene discussed is YWHAE; the disease is malignant colon neoplasm.