IGFBP3 and type 2 diabetes mellitus: Levels of circulating IGFBP3 were almost comparable between the study groups (Figure 1(d)); however, IGFBP3 was significantly higher in patients with DN (429.51 ± 21.36 μg/ml, P = 0.044) compared to people with T2D (360.2 ± 18.69 μg/ml).