BCL2 and acute kidney injury: As mentioned above [24, 25], there was an increase in Bax/ Bcl-2 ratio in many AKI models accompanied by the apoptosis of RTECs. In vivo experiments of this study showed that the mRNA gene and protein expression of proapoptotic factor Bax increased significantly compared with the control group, while the mRNA gene and protein expression of antiapoptotic factor Bcl-2 decreased obviously, suggesting that apoptotic regulatory factors played an important role.