Ultimately, for the composite IBD endoscopy score, the best predictive combination of inflammatory biomarkers was represented by the assembly of serum levels of SAA, IL-6, IL-8, and Eotaxin-1, showing an AuROC of 0.84 (SE: 0.05, 95% CI: 0.73–0.94, P < 0.0001, n = 64) (Figure 4A). This evidence concerns the gene IL6 and irritable bowel syndrome.