Although SBF2 is broadly expressed in the mouse (Kirfel et al., 2006), the phenotype of this model differs from the naturally occurring disease since no reduction in the sciatic nerve conduction velocity was observed at 12 months of age in mice (this is also the case in a mouse model of the MTMR2 neuropathy (Bonneick et al., 2005)), which markedly contrasts with the profound slowing of nerve conduction velocity observed in dogs (Houlden et al., 2001) and humans (Senderek et al., 2003; Azzedine et al., 2003; Hirano et al., 2004; Luigetti et al., 2013). The gene discussed is SBF2; the disease is neuropathy.