TLR4 and periodontitis: At present, the missense mutations in TLR4, rs4986790 (Asp299Gly) and rs4986791 (Thr399Ile), were the most commonly observed ones associated with periodontitis in Caucasian population (Chrzeszczyk, Konopka & Zietek, 2015; Ozturk & Vieira, 2009).