PDX1 and familial pancreatic carcinoma: Several TFs have been hypothesized to influence pancreatic cancer differentiation and development including: Pancreas/duodenum homeobox protein 1 (PDX1), pancreas transcription factor 1 subunit alpha (PTF1A), nuclear receptor subfamily 5 group A member 2 (NR5A2), hepatocyte nuclear factor 1-alpha (HNF1A) and hepatocyte nuclear factor 1-beta (HNF1B) [40].