PLIN5 and type 2 diabetes mellitus: HFFAs can aggravate HG-induced cardiac microvascular injury; Plin5 in CMECs plays a bidirectionally role in FFAs metabolism via the states of nonphosphorylation and phosphorylation; the deletion or the phosphorylation of Plin5 will break the balance of FFAs metabolism, result in the excessive production of FFAs and the overload of ROS, and eventually aggravate the CMECs injury induced by T2DM-HFFA.