The aims of this study are to determine (1) whether Plin5 is disturbed in diabetic CMECs, (2) whether the deficiency and phosphorylation of Plin5 affect the survival of CMECs under the condition of T2DM-HFFA, and, if so, (3) to identify whether oxidative stress participates in those biological effects of Plin5/p-Plin5 in CMECs. The gene discussed is PLIN5; the disease is type 2 diabetes mellitus.