The Trx system is a major antioxidant system integral to maintain the intracellular redox state and consists of Trx and TrxR, and the functions of this system in thiol-disulfide exchange reactions are essential to intracellular redox environment control, cellular growth, scavenging ROS, and apoptosis, thus displaying multiple roles in mammalian cells, including implications in cancer [48]. This evidence concerns the gene TXN and cancer.