The organotellurate immunomodulator AS101 induces G2/M arrest in myeloma cells and downregulates Cdc25C, Plk-1 (a serine/threonine kinase), and Ilk-1 (essential for regulating the activity of Akt) in mouse 5T33 myeloma cells [64, 65]. Here, AKT1 is linked to plasma cell myeloma.