In addition, to test Orai2 as a biomarker and a regulator of glioma stem cells, we further found a relationship between Orai2 and GSC markers, such as PROM1, NES, SOX2, OLIG2, NOTCH1, SOX9, MET, NOTCH2, and DLL3. The gene discussed is NOTCH1; the disease is central nervous system cancer.