As shown in Table 3, our meta-analysis showed statistical significance between HBV-positive carcinoma serums and HBV-negative carcinoma serums for the methylation of two genes, including p16 (the overall OR = 2.51, 95% CI = 1.16-5.44, p = 0.02) and APC (the overall OR = 5.11, 95% CI = 2.09-12.52, p = 0.0004). Here, APC is linked to carcinoma.