As shown in Figure 3, we found a statistical difference between HBV-positive carcinoma tissues and HBV-negative carcinoma tissues for GSTP1 methylation in China from six studies (OR = 2.13, 95% CI = 1.13-4.03, I2 = 0%, p = 0.02) and in Japan from five studies (OR = 4.29, 95% CI = 1.62-11.41, I2 = 0%, p = 0.003). This evidence concerns the gene GSTP1 and carcinoma.