The difference between the oe-AKT1-control and oe-AKT1-JSD groups was larger than that between the NC-control and NC-JSD groups (both, P < 0.001), suggesting that the ability of JSD to inhibit the healing ability of colon cancer cells was enhanced after AKT1 overexpression. Here, AKT1 is linked to malignant colon neoplasm.