As shown in Figure 11A, by day 21 there was a difference in mouse weight between the six groups (NC-control, NC-JSD, si-AKT1-control, si-AKT1-JSD, oe-AKT1-control, oe-AKT1-JSD) and by day 28, oe-AKT1-control mice had the heaviest weight due to ascites, large tumor load, and metastatic weight. Here, AKT1 is linked to neoplasm.