In summary, JSD may downregulate the EMT transcription factors Snail, Slug and Twist through the AKT/GSK-3β signaling pathway, leading to an upregulation of E-cad, and downregulation of N-cad and Vimentin, reversing EMT and inhibiting invasion and metastasis of colon cancer cells. Here, SNAI2 is linked to colonic neoplasm.