However, the difference between the si-AKT1-control and si-AKT1-JSD groups was less than that between the NC-control and NC-JSD groups (all, P < 0.05), suggesting that the ability of JSD to reverse EMT in colon cancer cells was mitigated by AKT1 knockdown. This evidence concerns the gene AKT1 and malignant colon neoplasm.