AKT1 and malignant colon neoplasm: Moreover, the difference between in the oe-AKT1-control and oe-AKT1-JSD groups was more than that between the NC-control and NC-JSD groups (both, P < 0.001), suggesting that the ability of JSD to inhibit the migration and invasion of colon cancer cells was enhanced after AKT1 overexpression.