Cell proliferation assay demonstrated that overexpression of SREBP1 remarkably reversed the inhibitory effect of PKD3 silencing on cell growth in DU145 and PC-3 cells, providing a key link between PKD3-mediated de novo lipogenesis through modulation of SREBP1 and cell proliferation in prostate cancer cells. The gene discussed is PRKD3; the disease is Familial prostate cancer.