SREBF1 and Familial prostate cancer: Given that the precursor form of SREBP1(125KD) is bound to the ER membrane and the mature form of SREBP1(68KD) translocates to the nucleus during starvation or sterol depleted condition 29, we investigated whether PKD3 regulates the formation of mature SREBP1(mSREBP1) and nuclear entry in prostate cancer cells.