To evaluate the correlation of PKD3 with expression of FASN and matured-SREBP1 (mSREBP1) as well as pathological progression of prostate cancer, we examined the expression of PKD3, FASN and mSREBP1 by immune-histochemical staining in a total of 80 prostate cancer specimens and 16 normal tissue cores, among which were 8 normal tissues adjacent to the tumors. This evidence concerns the gene PRKD3 and Familial prostate cancer.