TIMP1 and inborn error of immunity: According to the NES (normalized enrichment score) > 2, FDR (the false discovery rate) < 0.05 and the nominal P value < 0.05, high TGFB1, TIMP1 and VIM expression were mainly enriched in “primary immunodeficiency”, “ECM receptor interaction”, “cytokine receptor interaction” and “natural killer cell-mediated cytotoxicity” pathways (Fig. 7A-C).