Our results showed that CLEC4M suppressed the upregulation of cleaved caspase-3 that was induced by cisplatin in NSCLC cells; when CLEC4M expression is suppressed, the cisplatin-induced upregulation of cleaved caspase-3 was further increased, suggesting that CLEC4M inhibits cisplatin-induced apoptosis in NSCLC cells, which might be the molecular underpinnings of the role of CLEC4M in cisplatin resistance. The gene discussed is CASP3; the disease is non-small cell lung carcinoma.