Statistical analysis results showed that RAI14 expression was significantly correlated to lymph node metastasis (p<0.001) and advanced TNM stages (p<0.001), however, there was no difference between RAI14 expression and age (p=0.51), tumor size (p=0.804), estrogen receptor (ER) expression (p=0.513), progesterone receptor (PR) expression (p=0.775), and HER2 expression (p=0.204, Table 1). This evidence concerns the gene ESR1 and metastatic malignant neoplasm in the lymph nodes.