Although angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB), beta-blockers, and aldosterone antagonists have an abundance of evidence for preventing HF progression, and diuretics, vasodilators, antihypertensive drugs are widely used to relieve symptoms, approximately 60%∼80% HF patients have died in 5 years [1]. The gene discussed is ACE; the disease is hydrops fetalis.