REN and cardiac hypertrophy: In addition to inhibiting sympathetic activity, many animal experiments have explored other mechanisms of A&M in the treatment of HF and found that acupuncture can prevent fibrosis [49, 50], modulate inflammatory factors [51–53], inhibit the renin-angiotensin aldosterone system [54], improve the state of water sodium retention [55], reduce myocardial injury [56–59], protect myocardial contraction diastole function [60], inhibit myocardial hypertrophy, and reverse ventricular remodeling [50, 61].