As exhibited in Figure 2, compared with healthy controls, percentage of Treg, Tfh, Tfh1 (CD4+CXCR5+CXCR3+CCR4−), Tfh17 (CD4+CXCR5+CXCR3−CCR4−CCR6+) cells, and the Tfh1/Tfh2 ratio were significantly higher in patients with leiomyoma (all P values <0.05), while Th2 (CD4+CXCR5−CXCR3−CCR4+) and Tfh2 (CD4+CXCR5+CXCR3−CCR4+) cells decreased (both P values <0.001). This evidence concerns the gene CXCR5 and leiomyoma.