In this study, we firstly detected the expression of m6A methylation-associated genes (METTL3, FTO, ALKBH5, METTL14, YTHDF1, and YTHDF2) in PBMCs from RA patients and found that METTL3 was obviously upregulated in RA compared with healthy controls. The gene discussed is YTHDF1; the disease is rheumatoid arthritis.