In addition, our results demonstrate that while αS fibrils are indeed toxic to neuroblastoma cells (Fig. 4a), co-incubated αS/βS fibrils are not (Fig. 4a) and have a lesser tendency to cause the formation of synuclein aggregates and amyloid species compared with αS fibrils (Fig. 4b). Here, SNCA is linked to neuroblastoma.