IL6 and peritonitis: In a peritonitis model using Mx1-Cre-Hes1fl/fl mice, Hes1 deficiency promoted the expression of Cxcl1, resulting in enhanced recruitment of neutrophils into the peritoneum without affecting other cell populations.62 Furthermore, LPS-activated BMDMs derived from Hes1 conditional knockout mice expressed more Il6 and Il12b transcripts compared to control,63 implying an immunosuppressive role of Hes1 in MPs.