In a peritonitis model using Mx1-Cre-Hes1fl/fl mice, Hes1 deficiency promoted the expression of Cxcl1, resulting in enhanced recruitment of neutrophils into the peritoneum without affecting other cell populations.62 Furthermore, LPS-activated BMDMs derived from Hes1 conditional knockout mice expressed more Il6 and Il12b transcripts compared to control,63 implying an immunosuppressive role of Hes1 in MPs. Here, IL12B is linked to peritonitis.