As IL-7 contributed to Skp2 expression and cooperated with Notch activation in inducing cell cycle entry in healthy murine thymocytes (Fig. 2c; right panel), we validated these results in the IL-7-dependent T-ALL cell line, TAIL7 [31], and in primary T-ALL cells, which are responsive to IL-7 for survival and proliferation. This evidence concerns the gene SKP2 and acute lymphoblastic leukemia.