AKT1 and neoplasm: We found that human ASCs similarly stratified into the three subclasses identified by murine tumour phenotyping, namely: (i) ‘MAPK/mTOR’ signature tumours (ASC_9, 10, 12, 13; 4/13); (ii) ‘AKT/mTOR’ signature tumours (ASC_4, 6, 8; 3/13); and (iii) ‘Null’ signature tumours (ASC_1, 2, 3, 5, 7, 11; 6/13) (Fig. 4b).