Lesions of the three most common histopathology types in KL and KP GEMMs, namely adenosquamous carcinoma (ASC), confined to KL mice, as well as papillary adenocarcinoma (PAC) and invasive adenocarcinoma (IAC) (Fig. 2e) were subjected to quantification of p4EBP1 (marking mTOR), pAKT (marking AKT), pERK (marking MAPK), and pp38 (marking p38MAPK) expression (Fig. 2f, Supplementary Fig. S2a). Here, EIF2AK3 is linked to Tako-tsubo cardiomyopathy.