BMI-increasing alleles in FTO have been associated with lower brain, cortical gray matter, and nucleus accumbens volumes, reduced activity in brain areas important for emotion, impulse control and reward responsiveness, structural brain atrophy, reduced verbal fluency, increased loss of control episodes over eating, and decreased risk of stress/nervousness, alcohol dependence, depression, and suicide30. The gene discussed is FTO; the disease is depressive symptom measurement.