FTO and obesity due to melanocortin 4 receptor deficiency: This association is plausible, as (i) Universities in North America represent an obesity-prone environment for young adults22; (ii) SNPs in FTO are strongly associated with polygenic obesity in children and adults of European descent23; (iii) SNPs in FTO interact with obesity-prone environments to promote obesity24; (iv) an association between weight gain and FTO rs9939609 SNP (in strong linkage disequilibrium with rs3751812 in populations of European ancestry) has been previously reported in university students from the United Kingdom25.