Considering the important role of RPGRIP1L in cilium function26,31, and the critical link between cilium function, hyperphagic obesity and cognition (e.g. Bardet-Biedl syndrome)34, it is tempting to speculate that changes in brain expression of RPGRIP1L induced by FTO SNPs may also have an impact on impulsive behaviors. This evidence concerns the gene RPGRIP1L and obesity disorder.