SGOC metabolic pathway deregulation plays a role in cancers.15 We verified ILF3’s impact on SGOC and confirmed that ILF3 KD led to reduced expression of genes (PHGDH, PSAT1, PSPH, SHMT1, SHMT2, etc.)involved in the SGOC pathway (Fig. 2b, c). This evidence concerns the gene SHMT1 and cancer.