However, it needs to be emphasized that these CRC mutations (R70Q, R138C, L142I) like those mutations found in prostate cancer are clustered in central shallow groove of the MATH domain that binds to SBC of ILF3 (Supplementary information, Fig. S7f), thus compromising its impacts on degrading oncogenic ILF3 protein. This evidence concerns the gene ILF3 and colorectal carcinoma.