Significantly, applying uniformly carbon-13-labeled glucose ([U-13C] glucose) in metabolite tracing demonstrated that ILF3 KD in DLD1 cells leads to a pronounced decrease in the serine and glycine biosynthesis rates and serine and glycine pools in CRC cells (Fig. 2g–i; Supplementary information, S3d). Here, ILF3 is linked to colorectal carcinoma.