SPOP and colorectal carcinoma: We found that several CRC-derived SPOP mutations clustered within the MATH domain, and determined that these CRC-associated SPOP mutants (including R70Q, R138C and L142I) failed to regulate and interact with ILF3 (Supplementary information, Fig. S7c and d); therefore, they could not promote ILF3 poly-ubiquitination (Supplementary information, Fig. S7e).