PHGDH and colorectal carcinoma: With quantitative high-throughput screening, a previous report identified a new small-molecule PHGDH inhibitor, NCT-503.29 We performed cell viability assays and found that NCT-503 inhibited the growth of ILF3-high CRC cell lines in a dose-dependent manner, while ILF3-low CRC cells were less responsive (Supplementary information, Fig. S4a).