Six unique motifs were associated to this pathway, including E2F1..5, NR5A 1,2, POU2F1..3, TBP, TFDP1, and ZNF384. The motif activities of these TFs were significantly (false-discovery rate < 0.05, ANOVA test) down-regulated and the results correspond to the down-regulation of “Systemic lupus erythematosus (SLE)” pathway in most of the statin-treated cells (Supplementary Fig. 5). The gene discussed is E2F1; the disease is systemic lupus erythematosus.