DNMT1 and folate deficiency: B12 deficiency in combination with folate deficiency (BDFD) as well as over-supplementation (BDFO) led to increased mRNA levels of DNMT1 in the brain and liver whereas levels were decreased in the kidney (BDFN and BDFO) along with an increase in placenta (BDFN and BDFD) as compared to BNFN.