TCN2 and folate deficiency: B12 deficiency in combination to either condition of folate compared to control (BNFN), revealed an increase in the expression of TC-II in combination with folate normal (BDFN) and folate deficiency (BDFD) in the liver and placenta whereas expression was found to be decreased in kidney, however, in BDFO group increase in mRNA levels of TC-II was observed in brain and decreased in kidney.