FOLR1 and folate deficiency: Pairwise comparisons of BNFN with the condition of B12 deficiency in combination with either state of folate revealed that combination with folate deficiency (BDFD) led to an increase in mRNA levels of FOLR1 in all fetal tissues regardless of sex whereas, in combination with normal folate l (BDFN), the expression was increased in the liver (male and female) along with the brain (female).