Evaluation of intratumoral apoptosis by analyzing the expression of cleaved caspase 3 (C-caspase 3) and PARP (C-PARP) in OE33 xenograft tumor pooled lysates revealed significant increase after in-vivo treatment with lapatinib plus foretinib compared to control, lapatinib or foretinib treatment alone (Fig. 6a,b). Here, PARP1 is linked to neoplasm.