Explicitly, this represents all the cancers with at least five TCGA cases in all four groups: female mutant TP53, female wild-type (wt) TP53, male mutant TP53 and male wt TP53. Our calculations show for the first time that males have a higher probability of developing cancers with TP53 mutations than females, for the majority of non-reproductive cancers: subsequently referred to as the 12 disparity cancers (Fig. 1a; Table 1; Supplementary Table 1). This evidence concerns the gene TP53 and cancer.