GDF15 and Insulin resistance: Many clinical measures are associated with all-cause mortality or predict risk of mortality including C-reactive protein (CRP)16, red cell distribution width (RDW)17, homeostatic model assessment insulin resistance (HOMA-IR)18, growth differential factor 15 (GDF15; also known as MIC-1)19,20, total white blood cell (WBC) count21, serum albumin22, serum alkaline phosphatase (ALP), estimated glomerular filtration rate (eGFR), mean cell volume (MCV), triglycerides, cholesterol, elevated blood pressure and elevated body mass index (BMI)23.