Isopropyl dodecylfluorophosphonate (IDFP, Fig. 2a) is an isostere of monoacylglycerol that potently inhibits a broad range of mammalian neutral lipases (monoacylglycerol lipase, fatty acid amide hydrolase, KIAA1363) and phospholipases (ABHD3, ABHD6, neuropathy target esterase) with high selectivity over non-lipolytic enzymes such as acetylcholine esterase13. Here, NCEH1 is linked to neuropathy.