TP53 and neoplasm: For example, injection of adenovirus expressing Cre recombinase (Ad-Cre) into the ovarian bursae of mice bearing conditional alleles of tumor suppressor genes and/or oncogenes, such as Myc;Tp53;Brca130, Pten;Pik3ca31, Tp53;Rb132, or TgK18GT121 (N-terminal 121 amino acids of SV40 T antigen (T121) under the control of the keratin 18 promoter) and flTp53, +flBrca133, result in HGSOC-like tumors.