In detail, Laser+hydrogel–GNR (2) in G4 suppresses the secretions of IL1, IL6, IL8, IL10, IL12, CCL22, CCL17, and CCL5 that can promote progression and metastasis of tumor (Fig. 7h) and simultaneously augments the secretions of IL-5, IL-18, IL21, IFN-γ, and TNF-α associated with anti-tumor activity (Supplementary Fig. 20)36. This evidence concerns the gene IL21 and neoplasm.