In detail, Laser+hydrogel–GNR (2) in G4 suppresses the secretions of IL1, IL6, IL8, IL10, IL12, CCL22, CCL17, and CCL5 that can promote progression and metastasis of tumor (Fig. 7h) and simultaneously augments the secretions of IL-5, IL-18, IL21, IFN-γ, and TNF-α associated with anti-tumor activity (Supplementary Fig. 20)36. Here, CCL5 is linked to neoplasm.