In confocal immunofluorescence images we showed that pERK1/2 in HCT116 cells is predominantly localized in the cytoplasm (Fig. 1e), whereas in the three DAPK1 ko clones pERK1/2 expression was remarkably increased in the nuclei of tumor cells in vitro (Fig. 1e). The gene discussed is DAPK1; the disease is neoplasm.