Indeed, NAC treatment completely abolished chaetocin-mediated sensitization to TRAIL (Fig. 6a), to FasL (Fig. 6b) and to BH3 mimetic (Fig. 6c) in GBM and U87MG-TR cells (Supplementary Fig. 10), where PARP and Casp3 cleavage induced by chaetocin and TRAIL treatment was reduced in the presence of NAC (Fig. 6d). Here, CASP3 is linked to glioblastoma.