ANXA5 and glioblastoma: These results were supported by flow cytometric analysis of AnnexinV-positive and PI-positive cells, where the presence of enhanced early and late apoptotic cells were evident with both chaetocin and TRAIL treatment (Fig. 2g, h, Supplementary Fig. 2C–D) indicating that chaetocin and TRAIL cooperate to induce apoptosis in GBM cells.