PPARA and breast cancer: Furthermore, PPARɣ siRNA-mediated knockdown in UMUC1 prevented rosiglitazone-mediated reductions in TFAP2A mRNA and protein expression, as well as increased FABP4 mRNA and protein (Supplementary Fig. S4) These results suggests that TZD-induced repression of TFAP2A mRNA and protein requires a functional PPARɣ receptor in BC cells.